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Canagliflozin alleviates pulmonary hypertension by activating PPAR and inhibiting its S225 phosphorylation

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Sphingosine kinase 2 (SPHK2) can activate HDAC through the production of S1P, leading to histone H3K9 deacetylation and epigenetic remodeling of PASMCs, thereby promoting PAH vascular remodeling