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The results of the study also crucially provided evidence for the role of mismatch repair (MMR) enzyme MSH2 in repeat instability, demonstrating the potential for FRDA iPSCs to elucidate the molecular mechanisms underpinning FRDA pathology

In the medical world, theres science spelled with an s, Ebert said, and then theres science spelled with a dollar sign. (Researchers have estimated that the vaccines, and the massive campaign to make them accessible to the public, have saved as many as 3 million lives in the U.S

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Hepatic stellate cells (HSCs), when activated by ROS and damage-associated molecular patterns (DAMPs) from injured or necrotic hepatocytes, will produce extracellular matrix components to construct fibrotic tissue [36]

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