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In people with PD, glutathione levels are lower in the brain, specifically in the substantia nigra (the area in which dopamine cells are lost)

CHE was also reported to induce DNA damage, cell cytotoxicity, and disruption of plasma membrane integrity in L1210 leukemic cells, which were more sensitive to the toxic effect of CHE than normal mouse spleen cells

doi: 10.3390/jcm13071986 95 DuffinKMitchellRTBroughamMFHamerGvan PeltAMMulderCL

SCC47 exhibited increased expression of NADK compared to other cell lines, an enzyme necessary to phosphorylate NAD + to NADP+, reflected by its increased fold change in NADP + and NADPH, although narrowly significant (FC = 4.626.59, p = 0.0780.093) (Figs