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Cigarette smoking is related to increase in 2-hydroxylation pathway of E2 and decrease in bio-availability of oestrogen (Reference Michnovicz, Hershcopf and Naganuma40)

3.2 Sulforaphanes role in mitigating neuroinflammation Neuroinflammation is defined as an immune response within the central nervous system (CNS), characterized by the activation of microglia and astrocytes, increased pro-inflammatory cytokines, and potential disruption of neuronal homeostasis (DiSabato et al., 2016)