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The Society of Thoracic Surgery, 2016

However, regulation through DJ-1 seems to be more complex

However, protonation at a different site could not only influence thiol pK a values, but additional charge effects could also contribute to the overall reactivity of the molecule (79)

3 The approval of Resmetirom represents a major advancement in MASLD treatment, 4 offering a targeted therapy for patients with progressive MASH and moderate-to-severe liver fibrosis, thereby addressing a longstanding therapeutic gap