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In lung cancer, the loss of BRG1 or BRM components of the SWI/SNF chromatin remodeling complex activates the NRF2 signaling pathway, particularly increasing the expression of NRF2 target genes HMOX1 and GSTM4

detoxifies amines (serotonin, melatonin, histamine, tyramine, and all of the catecholamines: dopamine, norepinephrine, epinephrine), phenols (salicylic acidaspirin, cannabinoids, estradiol, and BPA), and many other chemicals