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The study authors concluded that the introduction of new bacteria and yeast strains into the gut microbiota prevented it from returning to normal in the usual timeframe

NAD+ levels naturally decline with age, stress, illness, and environmental exposures, which can contribute to fatigue, brain fog, slower recovery, and reduced resilience

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A single oral dose of up to 25 mg 4-DMAP/kg did not result in any macroscopic or histological abnormality in the gastrointestinal tract, liver, or kidneys of rats killed up to 24 h after dosing