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The enzyme l-GalDH generates cytosolic NADH, which has to be re-oxidized to allow the availability of NAD + and therefore sustain the reaction ( Figure 3 )

1307-1308, Vatva GIDC Phase 3, Ahmedabad, Gujarat, India

These findings open new avenues for therapeutic intervention, such as targeting mitochondrial quality control, mtDNA release, or cGAS-STING signaling to mitigate neuroinflammation and slow disease progression