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Much of this increase is explained by changes in diagnostic practice, including: Broadening the definition of ASD to include higher-functioning children Increased accuracy in the diagnosis of ASD (particularly for children who previously may have been diagnosed with intellectual disability) Increased awareness of the disorder Earlier identification of young children However, we cannot rule out that there is a true increase in the risk for ASD

Methionine synthase requires the cofactor cob(I)alamin, which becomes oxidized to cob(II)alamin, resulting in the inactivation of the enzyme

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