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FMa: Writing review & editing, Conceptualization, Funding acquisition

Lcn2 has been shown to be upregulated in DBA retina with age and increased IOP [51]

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Epacadostat, a highly potent IDO1 inhibitor, despite its initial promise in preclinical settings, demonstrated no clinical benefit in combination with the PD-1 inhibitor pembrolizumab in a large Phase III trial (NCT02752074), possibly due to compensatory mechanisms such as upregulation of IDO2 and tryptophan-2,3-dioxygenase (TDO), which sustains immunosuppressive kynurenine production (55)