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RNAscope assays were performed according to the protocol provided with an RNAscope Multiplex Fluorescent Detection kit v2 (323110, ACDBio) with minor modifications, where the hydrogen peroxide treatment was omitted, protease 3 was used instead of protease 4, and counterstaining with DAPI (1.0 g ml 1 , 10 min at room temperature) was performed

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