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This trial was the first to evaluate the use of oral N-acetylcysteine in monotherapy, associated with broad-spectrum sunscreen, for the treatment of melasma

These reactions are primarily mediated by UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs), which generate major circulating metabolites such as luteolin-7-O-glucuronide and luteolin-3-O-glucuronide ( in-vivo concentrations may fall below thresholds required to reproduce potent mechanistic effects demonstrated in vitro

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Nevertheless, individuals with both obesity and asthma exhibit a more pronounced increase in sputum neutrophils compared to those with non-obese asthma (138, 139), although an eosinophilic phenotype also exists in individuals with obesity and asthma (140, 141)

Vaccaro et al