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Its molecular structure was optimized through genetic engineering technology: an additional 13 amino acids were added to the N-terminus of natural IGF-1 (70 amino acids, molecular weight 7.4 kDa) to form a long-chain structure of 83 amino acids (molecular weight 9.11 kDa), and the third glutamic acid (Glu) was replaced with arginine (Arg), hence the name "R3"

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What adjustments look like in practice

Under the conditions of GSH 10 mM and pH 5.3 the drug release from nanogels were 89.2%, which was attributed to the dual-responsive nature of the nanosystem due to breakage of crosslinking and swelling of gels, respectively

doi: 10.1016/j.eplepsyres.2014.05.009