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Most proinflammatory cytokines such as IL-6, IL-1, TNF-, IL-8, and IFN as well as some anti-inflammatory mediators including -aminoisobutyric acid, A20 enzyme, and EPO have been shown to impair adipogenesis, leading to adipocyte hypertrophy, ectopic fat accumulation, and increased risk of IR and T2DM

The present results demonstrated that Klotho protein significantly contributed to inhibition of the IGF1R/PI3K/AKT signalling during heart IRI

These carriers improve the solubility of poorly water-soluble drugs and accommodate multiple therapeutic agents, making them versatile for oral, transdermal, and topical applications (Mahmoudian et al., 2021)

All animals were kept in temperature- and humidity-controlled rooms under a 12 h/12 h light/dark cycle

These free radicals come from everywhere: environmental pollutants, UV radiation, processed foods, and even the natural process of metabolism