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For example, microorganisms have been shown to directly interact with components of the bloodbrain barrier (BBB), leading to coagulopathy and tight junction disruption, inducing lung inflammation that results in hypoxia, and ultimately increasing BBB permeability ( In addition, the central invasion and infiltration of immune cells following viral pre-infection may serve as a trigger for NPP

Thus, current knowledge is largely hypothesis-generating and highlights the urgent need for well-designed clinical and translational studies