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29 , 480494 e5 (2019)

& Gong, D

These immune responses, including the release of pro-inflammatory cytokines (e.g., TNF-, IL-1), can signal to the brain via the vagus nerve and the systemic circulation (Ma et al., 2020)

For instance, research shows MOTS-c drives glucose into the pentose phosphate pathway (for anabolic needs and antioxidant defense) rather than burning it immediately via glycolysis, while simultaneously increasing fatty-acid oxidation by upregulating carnitine shuttle activity in mitochondria