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Common causes include: Poor dietary intake (common in vegans and vegetarians) Malabsorption disorders (e.g., pernicious anemia, celiac disease, Crohns disease) Certain medications (e.g., metformin, proton pump inhibitors) Aging (reduced stomach acid affects absorption) Alcoholism (impairs absorption) Gastrointestinal surgery (such as gastric bypass or removal of part of the stomach) What is the fastest way to fix B12 deficiency

Whilst the exact pathophysiology of PD still remains unclear, it is believed microvascular trauma, initiated by penile damage during sexual activity or due to repetitive minor trauma, leading to increased proliferation of fibroblasts and recruitment of profibrotic mediators leads to an excessive deposition of collagen

Table 3 Application related forms of ICD