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Unfortunately, even at levels of APAP that are currently considered acceptable, this situation will result in the exposure of some babies and children to levels of APAP toxicity that are much greater than those seen in typical, nonsusceptible individuals or in laboratory animals exposed to the same doses of APAP (Fig

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Crucially, synergistic interplay between these modalities, such as combining senolytics with epigenetic reprogramming or mTOR inhibition, should be rigorously explored to increase efficacy while minimizing unintended adverse effects

doi: 10.1172/JCI.INSIGHT.155827 52 Asadi-PooyaAAAkbariAEmamiALotfiMRostamihosseinkhaniMNematiHet al

Note: This material is intended for laboratory research use only