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Metformin therapy for pulmonary hypertension associated with heart failure with preserved ejection fraction versus pulmonary arterial hypertension

B 2018, 6 (8), 12791285

Conditional deletion of the circadian clock gene Bmal1 (brain and muscle ARNT-like 1, also known as Arntl ) in glomerular podocytes caused disruption of the circadian rhythm in GFR and parallel alterations in the circadian patterns of plasma aldosterone levels and urinary excretion of creatinine, sodium, potassium, and water (11)

Qin S, Liu Y, He G, Yang J, Zeng F, Lu Q, Wang M, He B, Song Y

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