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In the present study, we extend these findings by showing livers from GCLM KO mice exhibit a persistently greater level of oxidant stress as measured by protein carbonylation and expression of redox-sensitive genes

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Introduction The world of reconstructive transplantation is mature ( Mechanisms of IRI Ischemia leads to hypoxic anaerobic glycolysis and oxygen consumption, depleting adenosine triphosphate (ATP) and dysregulating ATP-dependent membrane ion exchangers ( Moreover, cellular acidosis can stimulate the antiport Na+/H+ receptors, worsening the sodium overload and affecting the function of other membrane receptors such as the Na+/Ca2+ antiport