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"Thyroid physiology and diagnostic evaluation of patients with thyroid disorders." Williams textbook of endocrinology: 334

This may likely be attributed to the anxiolytic effect of DMSO through suppression of oxidative stress which induces anxiety (Penazzia et al., 2017)

From a clinical perspective one can monitor the plasma concentration of NTBC and adjust the daily dosage to maintain a plasma level of between 40 to 60 M and be confident of satisfactory inhibition of the proximal tyrosine catabolic pathway