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10.1289/ehp.9785 40

Cell Death & Disease, 11 (9), 727

The integrin 1/5/JNK/c-JUN signaling pathway in cancer cells is able to upregulate the higher matrix stiffness-induced lysyl oxidase like (LOXL)-2, then subsequently promote production of fibronectin, expression of MMP-9 and C-X-C motif chemokine ligand (CXCL)-12 and recruitment of BMDCs to encourage pre-metastatic niche establishment (95)