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Acknowledgements Thanks to the editors and reviewers for their hard work and important comments

Of these, 47 returned a completed survey, a 71% overall response rate

These toxins deplete our energy and can even cause us to age more quickly

72 Previous Study has shown that SAH can reduce the expression of DNA methyltransferase DNMT1 protein, lead to demethylation of the CpG islands in the NF-B gene promoter region, and increase NF-B expression, trigger the expression of pro-inflammatory senescence-associated secretory phenotype (SASP) factors, and thus induce cellular senescence in rat aortic smooth muscle cells

Chronical consumption (8 weeks) of a pure arabica dark-roast coffee blend significantly reduced spontaneous DNA strand breaks in blood cells of healthy volunteers, pointing to a DNA protective effect (Pahlke, 2019) and (Schipp 2018)