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A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology

[DOI] [PMC free article] [PubMed] [Google Scholar] 200.Li G., Zhang Y., Thabane L., Mbuagbaw L., Liu A., Levine M.A., Holbrook A

Mesna detoxifies urotoxic metabolites formed from these two agents (e.g., oxazaphosphorine and acrolein), and by doing so, decreases the risk of bladder bleeding

Authors: Thomas Kruse, Jakob Lerche Hansen, Kirsten Dahl, Lauge Schffer, Ulrich Sensfuss, Christian Poulsen, Morten Schlein, Ann Maria Kruse Hansen, Claus Bekker Jeppesen, Charlotta Dornonville de la Cour, Trine Ryberg Clausen, Eva Johansson, Simone Fulle, Rikke Bjerring Skyggebjerg, Kirsten Raun URL: This paper details the medicinal chemistry efforts that led to the design and synthesis of cagrilintide, a long-acting amylin analogue for the treatment of obesity