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The translocated cyt c hijacks histone chaperones such as suppressor of variegation, enhancer of zeste and trithorax (SET)/template-activating factor (TAF)-I, inhibiting the nucleosome assembly/disassembly activity and DNA repairing ( c has also been identified as one of the components of brainstem Lewy bodies (Wakabayashi et al., 2007) and might play as a trigger in -Syn aggregation ( c according to an in vitro study ( in vivo and whether post-translational modifications of cyt c as mentioned earlier have any effects on these moonlight functions are still unknown