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The normal endogenous production of thiosulfate can therefore be considered to be small and the ability to produce increased amounts in response to poisoning is likely to be limited

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As shown in Figures 3CE, the activities of cleaved caspase 3, 8, and 9 were increased in a dose-dependent manner by treatment with increasing concentrations of ASP for 12 h in both cell lines

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Moreover, 5 mg/kg 3-bromopyruvate (glycolysis inhibitor) in a mouse with arthritis induced by K/BxN mouse serum reduces clinical score, proinflammatory cytokines in the joint, inflammatory cell infiltration, joint destruction, and cartilage damage 27 , which has made it possible to consider glycolysis pathway inhibition as a potential pharmacological target for RA 29