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isolated means that the material is removed from its original environment (e.g., the natural environment if it is naturally occurring)

Martin-McGill KJ, Bresnahan R, Levy RG, Cooper PN

An additional set of blots of nitrated bovine serum albumin (BSA) showed an immuno-positive response to anti-nitroY mAb while not to anti-nitroY250-HGF mAb, and hence served as a control and demonstrated high immuno-specificity of the anti-nitroY-HGF used here

In the context of CRC, the NO pathway metabolites are found to be altered, with enzymes such as ARG1, PRMT1, and PRMT5 being overexpressed in both tumor and tumor-adjacent tissues

By contrast, drugs that target metabolic pathways (e.g., GLUT1 inhibitors, PPP inhibitors, PDK inhibitors, and glutaminase inhibitors) may provide promising efficacy in ovarian cancer cells harboring nutrient addiction