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Indeed, we observe weaker binding of this mAb to 293-expressed gH/gL/gp42 compared with gH/gL alone

10.1016/j.jtemb.2014.11.002 [DOI] [PubMed] [Google Scholar] Eyster C

Various factors may have contributed to these mixed results, including participant heterogeneity, compliance issues, and the aggressive placebo response often seen in obesity trials where lifestyle modification is encouraged

This confirms an earlier, uncontrolled study showing that melatonin was helpful for patients with Crohns disease and ulcerative colitis (Rakhimova 2010)