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Its biochemical functions under physiological conditions include the metabolism of homocysteine (a cytotoxic molecule and cardiovascular risk factor) and the generation of hydrogen sulfide (H 2 S), a gaseous biological mediator with multiple regulatory roles in the vascular, nervous, and immune system

In fact, kynurenic acid is an antagonist of NMDA and all ionotropic glutamate receptors ( Important to know, kynurenine pathway abnormalities have been reported in migraine ( Riboflavin Can Ameliorate Glutamate Toxicity

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2), the thioether form is considerably more oxidation-resistant

Mol Cell (2014) 53(6):91628