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If lifestyle measures are insufficient , your GP may recommend: Osmotic laxatives (such as macrogol) are often recommended as first-line treatment for chronic constipation Bulk-forming laxatives (such as ispaghula husk) may be suitable when stools are small and hard, particularly with IBS-like symptoms Stimulant laxatives (such as senna or bisacodyl) for short-term use in resistant cases According to NICE Clinical Knowledge Summaries , laxatives should be used appropriately and reviewed regularly

424 In this study, all the DOACs examined showed similar stroke and systemic embolism risks

Guo S, Bragina O, Xu Y, Cao Z, Chen H, Zhou B, Morgan M, Lin Y, Jiang BH, Liu KJ, Shi H (2008) Glucose up-regulates HIF1 expression in primary cortical neurons in response to hypoxia through maintaining cellular redox status

Most importantly with regards to wound healing, NO plays an important role in pathogen clearance during the inflammatory stage, and this NO is produced by the inducible nitric oxide synthase (iNOS) isozyme 62,63

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