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These results were observed in a specific clinical population under controlled conditions and may not generalize to other groups

Physicians should also exercise caution when prescribing to patients with proliferative retinopathy or severe, uncontrolled diabetes, as GH can transiently affect insulin sensitivity

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The clinical development program was discontinued after reaching phase II trials

In a related study, mice that were fed a high fat diet had crown-like signs of macrophage infiltrations, while mice that were given a high fat diet and injected with SOD3 had minimal signs of infiltrate (Cui et al., 2014)