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The results revealed significant upregulation in lexA , recA , umuD , and OxyR expression following the addition of cystine alone (Figure 7A), which aligned with our expectations

Hence, C4d is frequently deposited at the site of complement activation, whereas C3a and C5a function as anaphylatoxins enhancing infiltration in the kidney with innate immune cells (neutrophils and mononuclear inflammatory cells) that exacerbate the injury

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IV administration bypasses this entirely