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Miyanaga N, Akaza H, Hinotsu S, Fujioka T et al (2012) Prostate cancer chemoprevention study: an investigative randomized control study using purified isoflavones in men with rising prostate-specific antigen

Microglial pro-inflammatory polarization is further sustained by dysregulated potassium (KCNJ2) and calcium (TRPM2) channels, creating a vicious cycle of cytokine release and immune activation