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This calls for a more detailed inquiry about the history of the disease

[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Tomasi ML, Tomasi I, Ramani K, Pascale RM, Xu J, Giordano P, Mato JM, Lu SC

L.FreemanJ

10.1371/journal.pone.0025935 146 NogueiraN

93 Thus, further elucidating how neurofibromin modulates oestrogen signalling and vice versa might shed light on the role of sex hormones in regulating tumour growth in NF1 patients, and ultimately provide a rationale for repurposing agents that target oestrogen in order to inhibit neurofibroma development