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The elevated PPP in cancer cells generates high NADPH levels to reduce ROS while simultaneously generating high levels of nucleotides for DNA synthesis and repair

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Liu X, Chen S, Chen M et al (2019a) Association study reveals genetic loci responsible for arsenic, cadmium and lead accumulation in rice grain in contaminated farmlands

Specifically, we found that GSSG elevation suppressed the phosphorylation/activation of IKK-, a proximal kinase in the NF-B signaling pathway that phosphorylates IB-, leading to its proteasomal degradation and subsequent NF-B activation