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doi: 10.3389/fimmu.2024.1362543 63 LiuXNieLZhangYYanYWangCColicMet al

In the RT structure, the cyano group at the position of the Michael acceptor enables fast reaction kinetics, the four-membered azetidine ring improves quantum yield and photostability 17 , and the two carboxylic acid groups ensure aqueous solubility and reduce probe binding to hydrophobic cellular structures