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In NAFLD, elevated plasma amino acids activate mTORC1 signaling, promoting hepatocyte proliferation while exacerbating iron toxicity [161]

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Hepatocytes are capable of synthesizing and secreting various biological signaling molecules, collectively known as hepatokines

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Even though it was expected in the previous study that a double deletion of the GST polymorphic gene will result in a decrease in the total GST enzyme activity, and play a role in disease conditions such as cancers [12,13], the contrary finding suggests that antioxidant enzymes activities in HIV patients may be influenced by other factors such as race, geographical location and trace elements