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CHARM Investigators

Skin biopsies of the Gottron papules demonstrate cellular infiltrates consisting of activated CD4+ lymphocytes (expressing HLA-DR and CD40L molecules) located in the perivascular areas of the upper dermis and subepidermally (14)

Remember: calling a study observational is not some kind of insult

It targets a range of substrates, including misfolded or oxidized proteins, tau, polyglutamine-expanded proteins, and key signaling factors (Lee et al., 2013

PMID: 36192391 Phytomedicine Motherwort synergized with oxytocin for postpartum hemorrhage prevention: Integrated clinical efficacy and mechanism exploration