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35,36 Activation of microglia occurs when A oligomers bind to receptors on the microglia cell surface, leading to the production and release of proinflammatory cytokines and chemokines, such as TNF- and IL-1

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Interestingly, evidence suggests that LL-37 and A 142 may in fact be natural binding partners that would be significant to the spatiotemporal ratios of the two peptides under disease conditions (De Lorenzi et al., 2017)

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