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May require supplementation with cofactors like magnesium and other B vitamins 9

Reducing mtDNA release The pathological release of mtDNA into the cytosol or extracellular spaceoften due to mitochondrial membrane permeabilization or dysfunctionis the initiating event driving mtDNA-induced inflammation

TABLE 2 Illustration of chemical structures of some bioactive secondary metabolites from white-rot fungi

Author contributions JC: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Project administration, Resources, Software, Visualization, Writingoriginal draft, Writingreview and editing

Reported mechanisms should be read as hypotheses from laboratory and animal data