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Key distinctions from growth hormone include [5] : Peptide lacks growth hormone receptor binding domains (specifically binding site 2) Binding site 2 is required for receptor dimerization and activation Competitive binding assays showed AOD9604 cannot compete with hGH for receptor binding Does not function as a growth hormone receptor antagonist Glucose Metabolism Preservation Unlike full hGH, which can induce insulin resistance and hyperglycemia, AOD9604 demonstrates no adverse effects on carbohydrate metabolism

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3.4 Additional mAbs raised with rMetE The rMetE was used to immunize mice and to isolate eight different additional mAbs that showed high binding affinity to rMetE protein, as measured by EC 50 and reported in Figure 1A