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In primary astrocyte OGD/R experiments, IC II (6.25 M) enhanced Nrf2 transcriptional activity, promoted its nuclear translocation, and activated the OXPHOS/NF-B/ferroptosis axis

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As with any medication, there is also a risk of rare but more serious side effects, such as priapism (prolonged erection), sudden hearing or vision loss, and allergic reactions

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Tryptophan metabolism is also impaired in patients with IBD [38], thus aggravating the severity of the disease

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