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Generation of XKR8-deficient HL-60 cells XKR8-deficient HL-60 cells were generated using CRISPRCas9 technology

Laboratory data, LMS (cT1), and index liver biopsy findings were reviewed

The intestine microbiota was enriched with functions related to carbohydrate metabolism, amino acid metabolism, energy metabolism, the metabolism of cofactors and vitamins, nucleotide metabolism, membrane transport, translation, lipid metabolism, and xenobiotics biodegradation and metabolism

In turn, biopsy of skin lesions showed superficial epidermal necrosis with dyskeratotic keratinocytes

Taking glutathione before bed provides antioxidant support during this critical period