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10.1155/2012/736837 J Amino Acids

Lerner AJ, Arnold SE, Maxfield E, Koenig A, Toth ME, Fortin B, Mast N, Trombetta BA, Denker J, Pieper AA, Tatsuoka C, Raghupathy S, Pikuleva IA (2022) CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimers disease

Such clinical findings were confirmed in vitro , with oxidative stress identified to be partially involved in NLRP3-mediated IL-1 secretion by monocyte cultures exposed to SARS-CoV-2