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J Pediatr Gastroenterol Nutr 55(3):321327

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It plays a crucial role in various bodily functions, including detoxification, immune response, and the maintenance of cellular health

Not only is there reduced production of melatonin and adrenalin in vitamin B12 deficiency, because of the requirement for methylation, there is also reduced production of CoQ10 and creatine , which are arguably the main contributing factors to the chronic fatigue seen in CFS, as these result in poor energy conversion, and gradual loss of stored muscle creatine