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DMSO-induced autophagy is controlled through ATF4-mediated downregulation of phosphorylated AKT1 To determine the pivotal role of ATF4 in DMSO-induced autophagy, we tested the RNA levels of ATF4 using reverse transcription polymerase chain reaction (RT-PCR)

Furthermore, as shown in Figure 1C, the important upstream side of the known M pro cleavage site at the nsp13/14 junction, NVATLQ/A, is remarkably similar to that of the active site sequence of GPx1, NVASLU/G, where the selenocysteine (U) lines up with a glutamine (Q) in the viral sequence

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In addition to mediating chemoresistance in tumor cells, zinc transporters also contributed to chemoresistance mediated in stroma cells