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Copper-Dependent Enzyme Activation Studies indicate that GHK-Cu provides copper for the activation of copper-dependent enzymes including lysyl oxidase (critical for collagen and elastin cross-linking), superoxide dismutase (SOD, an antioxidant enzyme), and tyrosinase

[122] confirmed that Bmal1 knockout directly reduces mitophagy and causes mitochondrial dysfunction

We introduced these concepts in a perspective review [7]

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