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Atrophic gastritis is often caused by Helicobacter pylori infection

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Animal model studies have preliminarily revealed that Clostridium colonization can curtail the overgrowth of pro-inflammatory microbiota, restore the intestinal mucosal barrier, and limit systemic translocation of bacterial LPS, ultimately reestablishing gut microbial homeostasis (206, 207)

Not because they're unsafe, but because the weight loss magnitude in controlled trials wasn't commercially viable compared to GLP-1 agonists or other obesity drugs

Diarrhea is another commonly reported gastrointestinal side effect that may range from mild loose stools to more significant episodes that could lead to fluid and electrolyte imbalances if severe or prolonged