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[6] Aphthous stomatitis has been associated with other autoimmune diseases, namely systemic lupus erythematosus, Behet's disease and inflammatory bowel diseases

The solution is hypertonic and liable to cause venous irritation at the site of injection if administered peripherally

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Systemic inflammation in T2D is further exacerbated by reduced levels of bacteria with anti-inflammatory activity that stimulate IL-10 and IL-22 secretion ( Roseburia , Akkermansia , Bacteroides , Faecalibacterium ), as well as those inducing Treg cells ( Clostridium clusters IV and XIVa)

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