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Moreover, the physician should consider the side effects of each approach and choose an overall low-risk, high-benefit treatment (Schirrmacher 2019)

478 Immune-responsive nanoscale drug carriers, such as DOX-MSN-SS-iRGD&1MT nanoparticles, have been developed to codeliver chemotherapy and ICIs across the BBB

By linking these engineering considerations to ongoing clinical and preclinical programs, we outline a structured analytical framework to inform rational design and platform selection in next-generation VLP-based vaccine development